Multiprotein complexes are essential mediators in the events leading to autophagy. On the structural level, however, little is known about their 3D architecture. Fundamental questions on the nature of these complexes need to be addressed:
- How are protein deposits structurally linked to autophagy?
- What are the shapes of these multiprotein assemblies at the membrane?
- How do they give rise to the cellular structure of the autophagosome?